![]() HSV serology Herpes simplex virus Uni-Gold™ Rapid.Ĭopyright © 2014 Elsevier B.V. gold standard University of Washington HSV western blot (UW-WB), were tested using Kalon by two technologists in an United States reference laboratory. The Western blot, developed by researchers at the University of Washington in. An accurate, near-person test allows immediate counseling directed toward symptom recognition, treatment, and practices that can limit the risk of HSV-2 transmission. Testing options for herpes simplex virus (HSV) have expanded in the United. The Uni-Gold™ HSV-2 Rapid had high sensitivity and specificity in a small sample of unselected, adults seeking care in the Seattle, USA area. Sensitivity for the Uni-Gold™ HSV-2 Rapid was 94% and specificity was 99%. The HSV Western blot used by the University of Washington laboratory uses nitrocellulose blots prepared with human diploid fibroblast-infected cell proteins. with the monoclonal antibody (MAb) ELISA and University of Washington Western blot. Six sera had indeterminate results by UWWB. Performance of Focus ELISA Tests for HSV-1 and HSV-2 Antibodies Among. For HSV-1, the researchers found that, among the 278 people whose immunoassay registered as positive, 255 were confirmed infected by blot test, suggesting that a positive immunoassay result for HSV-1 is likely reliable. Download Table Performance of the HSV-2 ELISA with Western blot analysis from publication: Performance of a Commercial, Type-Specific Enzyme-Linked Immunosorbent Assay for Detection of Herpes. Of 76 patients who were seronegative for HSV-2 by UWWB, 75 were correctly identified by the rapid test. This test, called the UW Western Blot is considered a highly accurate, gold standard test. Of 18 patients seropositive for HSV-2 by UWWB, 17 were correctly identified as such by the Uni-Gold™ HSV-2 Rapid. Sera from 100 adult patients in the USA were tested for HSV-2 specific antibodies by Uni-Gold™ HSV-2 Rapid and results were compared to those of the UWWB to determine the test's sensitivity and specificity. ![]() To evaluate the ability of the Uni-Gold™ HSV-2 Rapid to correctly diagnose the presence or absence of anti-HSV-2 antibodies in patient serum samples in comparison to the University of Washington HSV Western blot (UWWB). The Uni-Gold™ HSV-2 Rapid is a fast, point-of-care diagnostic test that can be performed outside a full service laboratory. These methods can be time consuming and expensive. HSV-2 diagnosis is typically by viral culture, viral DNA amplification of lesion material or by serology in cases of subclinical presentation. ![]()
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